In vitro study of drug sensitivity of Plasmodium falciparum: Evaluation of a new semi-micro test

A modification of Rieckmann's microtechnique was used to determine the drug sensitivity of Plasmodium falciparum. The technique was found to be reliable and adequately sensitive with either blood from a malarial patient or strains of P. falciparum from in vitro continuous culture, with a succes...

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Bibliographic Details
Published inThe American journal of tropical medicine and hygiene Vol. 32; no. 3; p. 447
Main Authors Le Bras, J, Deloron, P
Format Journal Article
LanguageEnglish
Published United States 01.05.1983
Subjects
Antimalarials - pharmacology
Chloroquine - pharmacology
Evaluation Studies as Topic
Mefloquine
Microbial Sensitivity Tests - methods
Plasmodium falciparum - drug effects
Quinine - pharmacology
Quinolines - pharmacology
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Summary:A modification of Rieckmann's microtechnique was used to determine the drug sensitivity of Plasmodium falciparum. The technique was found to be reliable and adequately sensitive with either blood from a malarial patient or strains of P. falciparum from in vitro continuous culture, with a success rate of 50%. Minor variations in the method had little influence on the results. Inhibition of maturation of parasites was compared with the inhibition of increase in parasitemia.
Bibliography:8292182
L72
ISSN:0002-9637
1476-1645
DOI:10.4269/ajtmh.1983.32.447