Facile preparation of ammonium alginate-derived nanofibers carrying diverse therapeutic cargo

Alginic acid was converted to a variety of ammonium alginate derivatives carrying diverse chemical cargo such as analgesics, antibiotics, and enzymes. These functional polymers could be fashioned into nanofibrous mats by electrostatic spinning. The therapeutic payload could be released in functional...

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Bibliographic Details
Published inChemical communications (Cambridge, England) Vol. 50; no. 2; pp. 156 - 158
Main Authors Pegg, Caitlin E, Jones, Gregory H, Athauda, Thushara J, Ozer, Ruya R, Chalker, Justin M
Format Journal Article
LanguageEnglish
Published England 07.01.2014
Subjects
Alginates - chemical synthesis
Alginates - chemistry
Ammonium Compounds - chemical synthesis
Ammonium Compounds - chemistry
Antibiotics
Drug Delivery Systems
Glucuronic Acid - chemical synthesis
Glucuronic Acid - chemistry
Hexuronic Acids - chemical synthesis
Hexuronic Acids - chemistry
Models, Molecular
Nanofibers - chemistry
Nanofibers - ultrastructure
Wound Healing
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Summary:Alginic acid was converted to a variety of ammonium alginate derivatives carrying diverse chemical cargo such as analgesics, antibiotics, and enzymes. These functional polymers could be fashioned into nanofibrous mats by electrostatic spinning. The therapeutic payload could be released in functional form by a simple ion exchange mechanism. Prospects in wound healing are discussed.
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ISSN:1359-7345
1364-548X
DOI:10.1039/c3cc47232a