Mean platelet volume in patients with dilated cardiomyopathy: does it have a role in left ventricular thrombus formation?

We assessed the clinical echocardiograhic, hematological, and biochemical parameters in patients with dilated cardiomyopathy (DCMP) and control individuals mainly focusing on the mean platelet volume (MPV) in terms of DCMP and left ventricle (LV) thrombus formation. Consecutive patients (n = 251) wi...

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Bibliographic Details
Published inAngiology Vol. 63; no. 7; p. 552
Main Authors Tekin, Gulacan, Sivri, Nasir, Tekin, Yusuf Kenan, Topal, Ergun, Erbay, Ali Riza, Yetkin, Ertan
Format Journal Article
LanguageEnglish
Published United States 01.10.2012
Subjects
Anticoagulants
Blood Specimen Collection
Cardiomyopathy, Dilated - blood
Edetic Acid
Heart Diseases - blood
Heart Ventricles
Humans
Platelet Count
Thrombosis - blood
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Summary:We assessed the clinical echocardiograhic, hematological, and biochemical parameters in patients with dilated cardiomyopathy (DCMP) and control individuals mainly focusing on the mean platelet volume (MPV) in terms of DCMP and left ventricle (LV) thrombus formation. Consecutive patients (n = 251) with DCMP and 266 patients without DCMP were studied. Mean platelet volume was significantly greater in patients with DCMP than in control patients (P < .05 for all comparisons). Comparing DCMP patients with LV thrombus (19 patients, 8%) and without LV thrombus (232 patients, 92%) showed that the prevalence of smokers was significantly higher and ejection fraction was significantly lower in patients with LV thrombus. We have shown that patients with DCMP have significantly higher MPV suggesting more platelet activation and the MPV of patients with DCMP and LV thrombus is comparable to those of patients without LV thrombus.
ISSN:1940-1574
DOI:10.1177/0003319711435146