Positional requirements for the stimulation of mRNA nuclear export by ALREX-promoting elements

The majority of vertebrate mRNAs that encode secreted, membrane-bound or mitochondrial proteins contain elements at the 5' end of the ORF that activate an alternative mRNA nuclear export (ALREX) pathway. Here we demonstrate that these elements promote efficient export and proper cytoplasmic loc...

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Bibliographic Details
Published inMolecular bioSystems Vol. 8; no. 10; pp. 2527 - 2530
Main Authors Tarnawsky, Stefan P, Palazzo, Alexander F
Format Journal Article
LanguageEnglish
Published England 01.01.2012
Subjects
Active Transport, Cell Nucleus - genetics
Animals
Cell Line, Tumor
Cell Nucleus - genetics
Cell Nucleus - metabolism
Cytoplasm - metabolism
Drosophila
Exons
Genes, Reporter
Genetic Engineering
Humans
Mice
Mitochondria
Nuclear transport
Open Reading Frames
Plasmids
RNA Transport - genetics
RNA, Messenger - chemistry
RNA, Messenger - genetics
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Summary:The majority of vertebrate mRNAs that encode secreted, membrane-bound or mitochondrial proteins contain elements at the 5' end of the ORF that activate an alternative mRNA nuclear export (ALREX) pathway. Here we demonstrate that these elements promote efficient export and proper cytoplasmic localization only when they are found at the 5' end of the transcript.
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ISSN:1742-206X
1742-2051
DOI:10.1039/c2mb25016k