Radiation adaptive response: the biophysical phenomenon and its theoretical description

• Published in: Radiation protection dosimetry Vol. 200; no. 16-18; p. 1585
• Main Authors: Fornalski, Krzysztof W, Adamowski, Łukasz, Bugała, Ernest, Jarmakiewicz, Rafał, Krasowska, Julianna, Piotrowski, Łukasz
• Format: Journal Article
• Language: English
• Published: England 13.11.2024
• Subjects: Adaptation, Physiological - radiation effects; Biophysical Phenomena; Computer Simulation; Dose-Response Relationship, Radiation; Humans; Models, Biological; Models, Theoretical; Monte Carlo Method; Radiation, Ionizing
• DOI: 10.1093/rpd/ncae053

The radiation adaptive response (or radioadaptation) effect is a biophysical and radiobiological phenomenon responsible for, e.g. the enhancement of repair processes, cell cycle and apoptosis regulation or enhancement of antioxidant production in cells/organisms irradiated by low doses and low dose-rates of ionising radiation. This phenomenon, however, is not always present, which creates many problems both for experimenters and theoreticians. Here we propose a comprehensive and complete theoretical model of radioadaptation grounded in mathematical concept of dose- and time-related probability function of the adaptive response appearance. This can be used in the context of two special cases of the adaptive response: the Raper-Yonezawa (priming dose) effect or constant low-dose-rate irradiation (e.g. for high natural background). This complete theoretical approach is supported by Monte Carlo simulations and real-experimental data used for model calibration and validation.