Radiation adaptive response: the biophysical phenomenon and its theoretical description

The radiation adaptive response (or radioadaptation) effect is a biophysical and radiobiological phenomenon responsible for, e.g. the enhancement of repair processes, cell cycle and apoptosis regulation or enhancement of antioxidant production in cells/organisms irradiated by low doses and low dose-...

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Published inRadiation protection dosimetry Vol. 200; no. 16-18; p. 1585
Main Authors Fornalski, Krzysztof W, Adamowski, Łukasz, Bugała, Ernest, Jarmakiewicz, Rafał, Krasowska, Julianna, Piotrowski, Łukasz
Format Journal Article
LanguageEnglish
Published England 13.11.2024
Subjects
Adaptation, Physiological - radiation effects
Biophysical Phenomena
Computer Simulation
Dose-Response Relationship, Radiation
Humans
Models, Biological
Models, Theoretical
Monte Carlo Method
Radiation, Ionizing
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Summary:The radiation adaptive response (or radioadaptation) effect is a biophysical and radiobiological phenomenon responsible for, e.g. the enhancement of repair processes, cell cycle and apoptosis regulation or enhancement of antioxidant production in cells/organisms irradiated by low doses and low dose-rates of ionising radiation. This phenomenon, however, is not always present, which creates many problems both for experimenters and theoreticians. Here we propose a comprehensive and complete theoretical model of radioadaptation grounded in mathematical concept of dose- and time-related probability function of the adaptive response appearance. This can be used in the context of two special cases of the adaptive response: the Raper-Yonezawa (priming dose) effect or constant low-dose-rate irradiation (e.g. for high natural background). This complete theoretical approach is supported by Monte Carlo simulations and real-experimental data used for model calibration and validation.
ISSN:1742-3406
DOI:10.1093/rpd/ncae053