Palladium-catalyzed oxidative direct C-H/C-H cross coupling of anilides with beta-keto esters

• Published in: Chemical communications (Cambridge, England) Vol. 49; no. 74; pp. 8214 - 8216
• Main Authors: Chan, Wai-Wing, Zhou, Zhongyuan, Yu, Wing-Yiu
• Format: Journal Article
• Language: English
• Published: CAMBRIDGE Royal Soc Chemistry 25.09.2013
• Subjects: Chemistry; Chemistry, Multidisciplinary; Cross coupling; Esters; Oxidants; Oxidizing agents; Palladium; Physical Sciences; Science & Technology; FUNCTIONALIZATION; ACTIVATION; OLEFINATION; BONDS; METAL; ALDEHYDES; ORTHO-ARYLATION; TERT-BUTYL HYDROPEROXIDE; SIMPLE ARENES; ALKENYLATION

A Pd(II)-catalyzed oxidative direct C(sp(2))-H/C(sp(3))-H cross coupling of anilides with alpha-dicarbonyl compounds with Mn(OAc)(3)center dot 2H(2)O as the oxidant is reported and this protocol provides facile access to alpha-aryl malonates and beta-keto esters in good yields and regioselectivity.