Palladium-catalyzed oxidative direct C-H/C-H cross coupling of anilides with beta-keto esters

A Pd(II)-catalyzed oxidative direct C(sp(2))-H/C(sp(3))-H cross coupling of anilides with alpha-dicarbonyl compounds with Mn(OAc)(3)center dot 2H(2)O as the oxidant is reported and this protocol provides facile access to alpha-aryl malonates and beta-keto esters in good yields and regioselectivity.

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Bibliographic Details
Published inChemical communications (Cambridge, England) Vol. 49; no. 74; pp. 8214 - 8216
Main Authors Chan, Wai-Wing, Zhou, Zhongyuan, Yu, Wing-Yiu
Format Journal Article
LanguageEnglish
Published CAMBRIDGE Royal Soc Chemistry 25.09.2013
Subjects
Chemistry
Chemistry, Multidisciplinary
Cross coupling
Esters
Oxidants
Oxidizing agents
Palladium
Physical Sciences
Science & Technology
FUNCTIONALIZATION
ACTIVATION
OLEFINATION
BONDS
METAL
ALDEHYDES
ORTHO-ARYLATION
TERT-BUTYL HYDROPEROXIDE
SIMPLE ARENES
ALKENYLATION
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Summary:A Pd(II)-catalyzed oxidative direct C(sp(2))-H/C(sp(3))-H cross coupling of anilides with alpha-dicarbonyl compounds with Mn(OAc)(3)center dot 2H(2)O as the oxidant is reported and this protocol provides facile access to alpha-aryl malonates and beta-keto esters in good yields and regioselectivity.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:1359-7345
1364-548X
DOI:10.1039/c3cc44769c