Application of the phylogenetic analysis in mitochondrial disease study

Mitochondrial disease currently received an increasing concern. However, the case-control design commonly adopted in this field is vulnerable to genetic background, population stratification and poor data quality. Although the phylogenetic analysis could help solve part of these problems, it has not...

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Bibliographic Details
Published inChinese science bulletin Vol. 53; no. 18; pp. 2733 - 2738
Main Authors Wang, ChengYe, Kong, QingPeng, Zhang, YaPing
Format Journal Article
LanguageEnglish
Published Heidelberg SP Science in China Press 01.09.2008
Subjects
Chemistry/Food Science
Earth Sciences
Engineering
Humanities and Social Sciences
Life Sciences
multidisciplinary
Physics
Science
Science (multidisciplinary)
population stratification
data quality
phylogenetic analysis
haplotype
mitochondrial disease
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Summary:Mitochondrial disease currently received an increasing concern. However, the case-control design commonly adopted in this field is vulnerable to genetic background, population stratification and poor data quality. Although the phylogenetic analysis could help solve part of these problems, it has not received adequate attention. This paper is a review of this method as well as its application in mitochondrial disease study.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1001-6538
2095-9273
1861-9541
2095-9281
DOI:10.1007/s11434-008-0380-8