Antitumor properties of platinum(iv) prodrug-loaded silk fibroin nanoparticles

Platinum(iv) complexes take advantage of the exclusive conditions that occur within the tumor to carry out their cytotoxic activity. On the other hand, silk fibroin has natural properties which make it very interesting as a biomaterial: high biocompatibility, biodegradability, low immunogenicity, hi...

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Published inDalton transactions : an international journal of inorganic chemistry Vol. 44; no. 30; pp. 13513 - 13521
Main Authors Lozano-Pérez, A Abel, Gil, Ana L, Pérez, Sergio A, Cutillas, Natalia, Meyer, Hajo, Pedreño, Mónica, D Aznar-Cervantes, Salvador, Janiak, Christoph, Cenis, Jose Luis, Ruiz, José
Format Journal Article
LanguageEnglish
Published England 14.08.2015
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Summary:Platinum(iv) complexes take advantage of the exclusive conditions that occur within the tumor to carry out their cytotoxic activity. On the other hand, silk fibroin has natural properties which make it very interesting as a biomaterial: high biocompatibility, biodegradability, low immunogenicity, high cellular penetration capacity and high reactive surface. Herein we report the preparation of silk fibroin nanoparticles (SFNs) loaded with the hydrophobic Pt(iv) complex cis,cis,trans-[Pt(NH(3))(2)Cl(2)(O(2)CC(6)H(5))(2)] (PtBz). Only a small fraction of the loaded PtBz is released (less than 10% after 48 h). PtBz-SFNs trigger strong cytotoxic effects against human ovarian carcinoma A2780 cells and their cisplatin-resistant variant A2780cisR cells. Interestingly, PtBz-SFNs are very cytotoxic (nanomolar IC(50) values) toward the triple negative breast tumor cell line MDA-MB-231, and also toward SK-BR-3 and MCF-7, while maintaining an excellent selectivity index.
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ISSN:1477-9226
1477-9234
DOI:10.1039/c5dt00378d