Biomechanical analysis of the effects of single high-dose vitamin D3 on fracture healing in a healthy rabbit model

• Published in: Archives of orthopaedic and trauma surgery Vol. 116; no. 5; pp. 271 - 274
• Main Authors: ÖMEROGLU, H, ATES, Y, AKKUS, O, KORKUSUZ, F, BICIMOGLU, A, AKKAS, N
• Format: Journal Article
• Language: English
• Published: Berlin Springer 01.05.1997; Springer Nature B.V
• Subjects: Animals; Biological and medical sciences; Biomechanical Phenomena; Biomechanics; Cholecalciferol - administration & dosage; Cholecalciferol - pharmacology; Femoral Fractures - physiopathology; Femur - drug effects; Femur - physiopathology; Fracture Healing - drug effects; Fractures; Fundamental and applied biological sciences. Psychology; Injections, Intramuscular; Male; Rabbits; Skeleton and joints; Vertebrates: osteoarticular system, musculoskeletal system; Vitamin D; Femur; Diseases of the osteoarticular system; Single dose; Rabbit; Lower limb; Impact study; Fracture; Lagomorpha; Trauma; Result; Biomechanics; Vertebrata; Experimental disease; Mammalia; Consolidation; Treatment; Animal; High dose; Strength; Colecalciferol
• ISSN: 0936-8051; 1434-3916
• DOI: 10.1007/bf00390051

In a previous ultrastructural study, the benefit of a single high dose of vitamin D3 on fracture healing in a healthy animal model was demonstrated. This study examined the biomechanical consequences of applying a single high dose of vitamin D3 in a healthy rabbit model subsequent to femoral fracture. The fracture load, the values of energy absorbed until fracture and the flexural rigidity values of the vitamin D group were significantly higher than the corresponding ones of the control group in the case of fracture. On the other hand, for intact bones, those values did not differ significantly between the two groups. It was concluded that single high-dose vitamin D3 application had positive effects on fracture healing in a healthy animal model, as far as the parameters related to mechanical strength are concerned.