Highly effective copper-mediated gem-difluoromethylenation of arylboronic acids

A copper-mediated gem-difluoromethylenation of aryl, heteroaryl and vinyl boronic acids with bromodifluoromethylated oxazole or thiazole derivatives has been developed. This novel reaction showed an excellent functional group tolerance and wide substrate scope, providing facile access to practical a...

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Published inChemical communications (Cambridge, England) Vol. 50; no. 56; pp. 7527 - 7530
Main Authors Ma, Guobin, Wan, Wen, Hu, Qingyang, Jiang, Haizhen, Wang, Jing, Zhu, Shizheng, Hao, Jian
Format Journal Article
LanguageEnglish
Published CAMBRIDGE Royal Soc Chemistry 18.07.2014
Subjects
Aromatic compounds
Boronic Acids - chemistry
Boronic Acids - metabolism
Chemistry
Chemistry, Multidisciplinary
Copper - chemistry
Copper - metabolism
Derivatives
Drugs
Functional groups
Hydrocarbons, Fluorinated - chemistry
Hydrocarbons, Fluorinated - metabolism
Methylation
Oxazole
Physical Sciences
Science & Technology
Substrates
Tolerances
BORONIC ACIDS
REAGENT
IODIDES
CROSS-COUPLING REACTIONS
PHOSPHONATES
FLUOROALKYLATION
ARYL
FLUORINATION
FACILE
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Summary:A copper-mediated gem-difluoromethylenation of aryl, heteroaryl and vinyl boronic acids with bromodifluoromethylated oxazole or thiazole derivatives has been developed. This novel reaction showed an excellent functional group tolerance and wide substrate scope, providing facile access to practical application in drug discovery and development.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:1359-7345
1364-548X
DOI:10.1039/c4cc03321c