Glyconanotechnology

• Published in: Chemical Society reviews Vol. 42; no. 10; pp. 4358 - 4376
• Main Authors: Reichardt, Niels C, Martín-Lomas, Manuel, Penadés, Soledad
• Format: Journal Article
• Language: English
• Published: England 21.05.2013
• Subjects: Biosensing Techniques; Biosensors; Drug delivery systems; Enzymes; Glycan; Glycomics; Glycoside Hydrolases - antagonists & inhibitors; Humans; Lectins - analysis; Medical; Nanomaterials; Nanoparticles - chemistry; Nanostructure; Nanotechnology; Nanotubes, Carbon - chemistry; Neoplasms - diagnosis; Neoplasms - metabolism; Neoplasms - pathology; Polysaccharides - analysis; Polysaccharides - chemistry; Quantum Dots; Vaccines, Conjugate - chemistry; Vaccines, Conjugate - immunology
• ISSN: 0306-0012; 1460-4744
• DOI: 10.1039/c2cs35427f

Glyconanotechnology can be seen as the synergy between nanotechnology and glycan related biological and medical problems. This review focuses on the crosstalk of glycoscience and nanotechnology, which will lead to a deeper understanding of glycobiology and to new glyco-materials with improved design and synergistic properties derived from glycoscience concepts for future nanodevices. It is intended to provide the glycoscientist with an application-oriented entry to the possibilities of nanotechnologies for his research. The most recent examples of glyco-nanomaterials as multivalent scaffolds for drug delivery, enzyme inhibition and for vaccine development, glycan functionalized quantum dots and nanoparticles in molecular imaging, biosensors for lectin/glycan detection based on nanomaterials, and new concepts for the affinity separation and analysis using nanomaterials or nanotools are revised.