Recent advances in preclinical and clinical multimodal MR in the newborn brain

[Display omitted] •MRI is the tool of choice for translational research in neuro-neonatal research.•MRI has allowed a better definition of injury in the newborn brain.•MRI has enabled incredible progress in the management of brain injury for the benefits of newborns worldwide.•The future of MRI will...

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Bibliographic Details
Published inJournal of magnetic resonance (1997) Vol. 292; pp. 149 - 154
Main Authors Enguix, Vicente, Ding, Yang, Lodygensky, Gregory A.
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.07.2018
Subjects
ADC
Asphyxia
Clinical MRI
fcMRI
HIE
High magnetic field: DTI
Inflammatory injury
MRS
Newborn brain
Preclinical MRI
White matter injury
ADC
Preclinical MRI
High magnetic field: DTI
HIE
Inflammatory injury
White matter injury
Clinical MRI
Asphyxia
fcMRI
Newborn brain
MRS
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Summary:[Display omitted] •MRI is the tool of choice for translational research in neuro-neonatal research.•MRI has allowed a better definition of injury in the newborn brain.•MRI has enabled incredible progress in the management of brain injury for the benefits of newborns worldwide.•The future of MRI will be its use in targeted neuroprotection of the most vulnerable infants. Aside from injury identification, MRI of the newborn brain has given us insight into cortical and white matter development, identified windows of vulnerabilities, enabled the introduction of therapeutic hypothermia which has become the standard of care in neonatal asphyxia, and is fostering leapfrogging discoveries in the field of neuro-genetics. This article reviews the main advances in recent years in newborn brain imaging both in preclinical and clinical research.
ISSN:1090-7807
1096-0856
DOI:10.1016/j.jmr.2018.04.017