Synthesis and Investigation of Biological Activity of New Betulonic Acid Derivatives Containing 1,2,3-Triazole Fragments

• Published in: Molecules (Basel, Switzerland) Vol. 29; no. 13; p. 3149
• Main Authors: Jalmakhanbetova, Roza I, Mukusheva, Gulim K, Abdugalimov, Alisher Sh, Zhumagalieva, Zharkyn Zh, Dehaen, Wim, Anthonissen, Stijn, Suleimen, Yerlan M, Seidakhmetova, Roza B
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 02.07.2024
• Subjects: Acids; Anti-Bacterial Agents - chemical synthesis; Anti-Bacterial Agents - chemistry; Anti-Bacterial Agents - pharmacology; betulonic acid; Biological activity; Breast cancer; chemical transformation; Chromatography; Colorectal cancer; Cytotoxicity; Escherichia coli - drug effects; Humans; Leukemia; lupane; Mass spectrometry; Metabolites; Microbial Sensitivity Tests; Molecular Structure; natural product; Ovarian cancer; Scientific imaging; Staphylococcus aureus - drug effects; Structure-Activity Relationship; synthesis; Triazoles - chemical synthesis; Triazoles - chemistry; Triazoles - pharmacology; triterpenoid; synthesis; triterpenoid; lupane; spectroscopic method; natural product; betulonic acid; antimicrobial activity; cytotoxicity; chemical transformation
• ISSN: 1420-3049; 1420-3049
• DOI: 10.3390/molecules29133149

The results of this study showed that the compounds synthesized by the authors have significant potential due to their antibacterial and cytotoxic properties. The apparent antibacterial activity demonstrated by the compounds suggests that they are active antimicrobial agents against common microbial pathogens that cause various socially significant infectious diseases. Compound showed pronounced antimicrobial activity against the Gram-positive test strain ATCC 6538, and compound demonstrated pronounced antimicrobial activity against the Gram-negative test strain ATCC 25922 (MIC = 6.3 µg/mL). This allowed us to consider these compounds to have great potential.