Steric effects of aryl aldehydes on a multicomponent one-pot synthesis of imidazoles

The one-pot reaction of an aryl aldehyde with 2-cyanopyridine and ammonium acetate in refluxing acetic acid produced the known 2-(2'-pyridyl)imidazole and fused imidazoles. This suggests that the steric effect of aryl rings plays an important role in these syntheses. A possible mechanism of the...

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Bibliographic Details
Published inJournal of chemical research Vol. 36; no. 9; pp. 557 - 559
Main Authors Li, Ruohan, Xiao, Shuzhang, Zhang, Meng, Nie, Zhaomin, Xiao, Rong, Hu, Longhai
Format Journal Article
LanguageEnglish
Published LONDON Sage 01.09.2012
Sage Publications Ltd
Subjects
Acetic acid
Chemistry
Chemistry, Multidisciplinary
Physical Sciences
Science & Technology
imidazole
characterisation
multi-component one-pot synthesis
steric effect of aryl rings
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Summary:The one-pot reaction of an aryl aldehyde with 2-cyanopyridine and ammonium acetate in refluxing acetic acid produced the known 2-(2'-pyridyl)imidazole and fused imidazoles. This suggests that the steric effect of aryl rings plays an important role in these syntheses. A possible mechanism of the reaction is discussed.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
ISSN:1747-5198
2047-6507
DOI:10.3184/174751912X13419400774706