Efficient kinetic resolution of racemic amines using a transaminase in combination with an amino acid oxidase

A range of enantiomerically pure (R)- and (S)-configured chiral amines has been prepared in excellent e.e. (99%) by combining a transaminase enzyme with an amino acid oxidase and catalytic quantities of pyruvate.

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Bibliographic Details
Published inChemical communications (Cambridge, England) no. 16; pp. 2127 - 2129
Main Authors Truppo, Matthew D, Turner, Nicholas J, Rozzell, J David
Format Journal Article
LanguageEnglish
Published England 01.01.2009
Subjects
Amines - chemistry
Amino Acid Oxidoreductases - chemistry
Catalysis
Kinetics
Stereoisomerism
Transaminases - chemistry
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Summary:A range of enantiomerically pure (R)- and (S)-configured chiral amines has been prepared in excellent e.e. (99%) by combining a transaminase enzyme with an amino acid oxidase and catalytic quantities of pyruvate.
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ISSN:1359-7345
1364-548X
DOI:10.1039/b902995h