Highly sensitive and selective miRNA detection based on a closed ring probe and multiple signal amplification

A highly sensitive and selective miRNA detection approach based on a small circular probe and dual signal amplification has been reported. We successfully applied the assay for quantitative let-7a detection in cell lysates and the results agreed well with those of qRT-PCR.

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Bibliographic Details
Published inChemical communications (Cambridge, England) Vol. 52; no. 96; pp. 13905 - 13908
Main Authors Tang, Yaqin, He, Xiao, Zhou, Zhenxia, Tang, Jiakun, Guo, Rong, Feng, Xuli
Format Journal Article
LanguageEnglish
Published England 01.01.2016
Subjects
Amplification
Assaying
Circularity
Ribonucleic acids
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Summary:A highly sensitive and selective miRNA detection approach based on a small circular probe and dual signal amplification has been reported. We successfully applied the assay for quantitative let-7a detection in cell lysates and the results agreed well with those of qRT-PCR.
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ISSN:1359-7345
1364-548X
DOI:10.1039/c6cc07719f