Stress dynamically reduces sleep depth: temporal proximity to the stressor is crucial

• Published in: Cerebral cortex (New York, N.Y. 1991) Vol. 33; no. 1; pp. 96 - 113
• Main Authors: Beck, Jonas, Loretz, Erna, Rasch, Björn
• Format: Journal Article
• Language: English
• Published: United States Oxford University Press 15.12.2022
• Subjects: Anxiety; Arousal - physiology; Cognition - physiology; Female; Humans; Original; Sleep - physiology; sleep; stress; cognition; slow-waves; arousal
• ISSN: 1047-3211; 1460-2199
• DOI: 10.1093/cercor/bhac055

The anticipation of a future stressor can increase worry and cognitive arousal and has a detrimental effect on sleep. Similarly, experiencing a stressful event directly before sleep increases physiological and cognitive arousal and impairs subsequent sleep. However, the effects of post- vs. pre-sleep stress on sleep and their temporal dynamics have never been directly compared. Here, we examined the effect of an anticipated psychosocial stressor on sleep and arousal in a 90-min daytime nap, in 33 healthy female participants compared to an anticipated within-subject relaxation task. We compared the results to an additional group (n = 34) performing the same tasks directly before sleep. Anticipating stress after sleep reduced slow-wave activity/beta power ratio, slow-wave sleep, sleep spindles, and slow-wave parameters, in particular during late sleep, without a concomitant increase in physiological arousal. In contrast, pre-sleep psychosocial stress deteriorated the same parameters during early sleep with a concomitant increase in physiological arousal. Our results show that presleep cognitions directly affect sleep in temporal proximity to the stressor. While physiological arousal mediates the effects of presleep stress on early sleep, we suggest that effects during late sleep originate from a repeated reactivation of mental concepts associated with the stressful event during sleep.