Extending the tissue penetration capability of conventional photosensitisers: a carbon quantum dot-protoporphyrin IX conjugate for use in two-photon excited photodynamic therapy

A carbon quantum dot (CQD)-protoporphyrin (IX) sensitisier conjugate was designed to exploit the large two-photon absorption cross section of CQDs and enable the indirect excitation of the sensitiser with 800 nm irradiation via FRET.

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Bibliographic Details
Published inChemical communications (Cambridge, England) Vol. 49; no. 79; pp. 8934 - 8936
Main Authors Fowley, Colin, Nomikou, Nikolitsa, McHale, Anthony P, McCaughan, Bridgeen, Callan, John F
Format Journal Article
LanguageEnglish
Published England 11.10.2013
Subjects
Absorption cross sections
Animals
Capture cross sections
Carbon
Carbon - chemistry
Cell Survival - drug effects
Conjugates
Disease Models, Animal
Excitation
Fibrosarcoma - drug therapy
Fluorescence Resonance Energy Transfer
HeLa Cells
Humans
Irradiation
Light
Mice
Penetration
Photochemotherapy
Photodynamic therapy
Photons
Photosensitizing Agents - chemistry
Photosensitizing Agents - therapeutic use
Photosensitizing Agents - toxicity
Protoporphyrins - chemistry
Quantum Dots - chemistry
Qunatum dots
Transplantation, Heterologous
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Summary:A carbon quantum dot (CQD)-protoporphyrin (IX) sensitisier conjugate was designed to exploit the large two-photon absorption cross section of CQDs and enable the indirect excitation of the sensitiser with 800 nm irradiation via FRET.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:1359-7345
1364-548X
DOI:10.1039/c3cc45181j