Dual role of p-tosylchloride: copper-catalyzed sulfenylation and metal free methylthiolation of imidazo[1,2-a]pyridines

• Published in: Organic & biomolecular chemistry Vol. 14; no. 7; pp. 2282 - 2290
• Main Authors: Ravi, Chitrakar, Chandra Mohan, Darapaneni, Adimurthy, Subbarayappa
• Format: Journal Article
• Language: English
• Published: CAMBRIDGE Royal Soc Chemistry 01.01.2016
• Subjects: Chemistry; Chemistry, Organic; Physical Sciences; Science & Technology; FUNCTIONALIZATION; ACTIVATION; REGIOSELECTIVE SULFENYLATION; THIOLATION; IMIDAZOHETEROCYCLES

Copper-catalyzed regioselective C-3 sulfenylation of imidazo[1,2- a ]pyridines using p -tosylchloride as a benign source of sulfenylating agents has been developed. On the other hand, p -tosylchloride mediated thiomethylation of imidazo[1,2- a ]pyridines with dimethylsulfoxide as a source of thiomet...