Dual role of p-tosylchloride: copper-catalyzed sulfenylation and metal free methylthiolation of imidazo[1,2-a]pyridines

Copper-catalyzed regioselective C-3 sulfenylation of imidazo[1,2- a ]pyridines using p -tosylchloride as a benign source of sulfenylating agents has been developed. On the other hand, p -tosylchloride mediated thiomethylation of imidazo[1,2- a ]pyridines with dimethylsulfoxide as a source of thiomet...

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Bibliographic Details
Published inOrganic & biomolecular chemistry Vol. 14; no. 7; pp. 2282 - 2290
Main Authors Ravi, Chitrakar, Chandra Mohan, Darapaneni, Adimurthy, Subbarayappa
Format Journal Article
LanguageEnglish
Published CAMBRIDGE Royal Soc Chemistry 01.01.2016
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
FUNCTIONALIZATION
ACTIVATION
REGIOSELECTIVE SULFENYLATION
THIOLATION
IMIDAZOHETEROCYCLES
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Summary:Copper-catalyzed regioselective C-3 sulfenylation of imidazo[1,2- a ]pyridines using p -tosylchloride as a benign source of sulfenylating agents has been developed. On the other hand, p -tosylchloride mediated thiomethylation of imidazo[1,2- a ]pyridines with dimethylsulfoxide as a source of thiomethylation under metal-free conditions was also described.
ISSN:1477-0520
1477-0539
DOI:10.1039/C5OB02475G