Advances in ophthalmic drug delivery

Various strategies for ocular drug delivery are considered; from basic formulation techniques for improving availability of drugs; viscosity enhancers and mucoadhesives aid drug retention and penetration enhancers promote drug transport into the eye. The use of drug-loaded contact lenses and ocular...

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Bibliographic Details
Published inTherapeutic delivery Vol. 5; no. 12; p. 1297
Main Authors Morrison, Peter W J, Khutoryanskiy, Vitaliy V
Format Journal Article
LanguageEnglish
Published England 01.12.2014
Subjects
Absorbable Implants
Biological Availability
Contact Lenses
Drug Delivery Systems - methods
Eye Diseases - drug therapy
Humans
Intravitreal Injections
Nanoparticles - chemistry
Ointments - administration & dosage
Ointments - chemistry
Ointments - pharmacokinetics
Ophthalmic Solutions - administration & dosage
Ophthalmic Solutions - chemistry
Ophthalmic Solutions - pharmacokinetics
Solubility
Tissue Adhesives - chemistry
Viscosity
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Summary:Various strategies for ocular drug delivery are considered; from basic formulation techniques for improving availability of drugs; viscosity enhancers and mucoadhesives aid drug retention and penetration enhancers promote drug transport into the eye. The use of drug-loaded contact lenses and ocular inserts allows drugs to be better placed where they are needed for more direct delivery. Developments in ocular implants gives a means to overcome the physical barriers that traditionally prevented effective treatment. Implant technologies are under development allowing long-term drug delivery from a single procedure, these devices allow posterior chamber diseases to be effectively treated. Future developments could bring artificial corneas to eliminate the need for donor tissue and one-off implantable drug depots lasting the patient's lifetime.
ISSN:2041-5990
DOI:10.4155/TDE.14.75