Synthesis and anti-toxoplasmosis activity of 4-arylquinoline-2-carboxylate derivatives

A one-step synthesis of 4-arylquinoline-2-carboxylates along with their antiprotozoal activity against the pathogenic parasite Toxoplasma gondii is reported. Mechanistic insights into the role of Lewis acid (silver triflate) versus Bronsted acid (triflic acid) catalysis are revealed clarifying aspec...

Full description

Saved in:
Bibliographic Details
Published inOrganic & biomolecular chemistry Vol. 12; no. 2; pp. 255 - 260
Main Authors McNulty, James, Vemula, Ramesh, Bordon, Claudia, Yolken, Robert, Jones-Brando, Lorraine
Format Journal Article
LanguageEnglish
Published CAMBRIDGE Royal Soc Chemistry 14.01.2014
Subjects
Antiprotozoal Agents - chemical synthesis
Antiprotozoal Agents - chemistry
Antiprotozoal Agents - pharmacology
Chemistry
Chemistry, Organic
Dose-Response Relationship, Drug
Molecular Structure
Parasitic Sensitivity Tests
Physical Sciences
Quinolines - chemical synthesis
Quinolines - chemistry
Quinolines - pharmacology
Science & Technology
Structure-Activity Relationship
Toxoplasma - drug effects
Toxoplasma gondii
Toxoplasmosis - drug therapy
QUINOLINE
POTENT
TANDEM SYNTHESIS
AMINES
3-COMPONENT REACTION
NATURAL-PRODUCTS
ALDEHYDES
INHIBITORS
ALKYNES
Online AccessGet full text

Cover

More Information
Summary:A one-step synthesis of 4-arylquinoline-2-carboxylates along with their antiprotozoal activity against the pathogenic parasite Toxoplasma gondii is reported. Mechanistic insights into the role of Lewis acid (silver triflate) versus Bronsted acid (triflic acid) catalysis are revealed clarifying aspects of the mechanism of the quinoline synthesis.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1477-0520
1477-0539
DOI:10.1039/c3ob41539b