Clinical efficacy of centrifugal-membranous hybrid double filtration plasmapheresis and membranous double filtration plasmapheresis on severe lupus nephritis

• Published in: Lupus Vol. 32; no. 9; pp. 1066 - 1074
• Main Authors: Dong, Jianhua, Huang, Li, Li, Chuan, WU, Bian, Yang, Xi, Ge, Yongchun
• Format: Journal Article
• Language: English
• Published: London, England SAGE Publications 01.08.2023; Sage Publications Ltd
• Subjects: Apheresis; Bleeding; Creatinine; Filtration; Hemoglobin; Humans; Lupus; Lupus Erythematosus, Systemic - complications; Lupus nephritis; Lupus Nephritis - complications; Lupus Nephritis - therapy; Nephritis; Patients; Plasmapheresis; Retrospective Studies; Treatment Outcome; severe lupus nephritis; hybrid; clinical efficacy; adverse events; Double-filtration plasmapheresis
• ISSN: 0961-2033; 1477-0962
• DOI: 10.1177/09612033231187229

Objective The study delves into the clinical efficacy and safety of centrifugal-membranous hybrid double filtration plasmapheresis (C/M hybrid DFPP) on severe lupus nephritis (LN) by comparing it with membranous DFPP (M DFPP). Methods A retrospective cohort study was conducted in 70 patients who were diagnosed with severe LN and had received DFPP treatment. Results A total of 181 DFPPs were performed, including 133 C/M hybrid DFPPs (51 patients) and 48 M DFPPs (19 patients).The ANA, A-dsDNA titer, quantitative urinary protein, and serum creatinine decreased significantly and hemoglobin increased significantly after the DFPP treatment and at third month after treatment. Two patients in the M DFPP group developed bleeding complications, and four patients in the C/M hybrid DFPP group developed perioral numbness. Conclusion Although there was no significant difference in clinical efficacy between C/M hybrid DFPP and M DFPP on severe LN, the risk of bleeding complications was significantly lower in the C/M hybrid DFPP group.