An efficient two-photon fluorescent probe for monitoring mitochondrial singlet oxygen in tissues during photodynamic therapy

A promising two-photon fluorescent probe MNAH for detecting O during the PDT process in mitochondria was proposed for the first time. MNAH was successfully applied for two-photon imaging of O in living cells and tissues during the PDT process with deep-tissue imaging depth. MNAH can be a powerful mo...

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Published inChemical communications (Cambridge, England) Vol. 52; no. 83; pp. 12330 - 12333
Main Authors Liu, Hong-Wen, Xu, Shuai, Wang, Peng, Hu, Xiao-Xiao, Zhang, Jing, Yuan, Lin, Zhang, Xiao-Bing, Tan, Weihong
Format Journal Article
LanguageEnglish
Published England 01.01.2016
Subjects
Cells (biology)
Fluorescence
Fluorescent Dyes - chemistry
HeLa Cells
Humans
Imaging
Mitochondria
Mitochondria - metabolism
Monitoring
Photochemotherapy
Photodynamic therapy
Photons
Singlet oxygen
Singlet Oxygen - analysis
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Summary:A promising two-photon fluorescent probe MNAH for detecting O during the PDT process in mitochondria was proposed for the first time. MNAH was successfully applied for two-photon imaging of O in living cells and tissues during the PDT process with deep-tissue imaging depth. MNAH can be a powerful molecular tool for studying O generation in mitochondria during the PDT process.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1359-7345
1364-548X
DOI:10.1039/c6cc05880a