Cucurbitacin B and Its Derivatives: A Review of Progress in Biological Activities

The emergence of natural products has provided extremely valuable references for the treatment of various diseases. Cucurbitacin B, a tetracyclic triterpenoid compound isolated from cucurbitaceae and other plants, is the most abundant member of the cucurbitin family and exhibits a wide range of biol...

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Published inMolecules (Basel, Switzerland) Vol. 29; no. 17; p. 4193
Main Authors Nie, Wenzhe, Wang, Yalan, Tian, Xinlu, Liu, Jinying, Jin, Zhanhui, Xu, Junjie, He, Miaohai, Shen, Qingkun, Guo, Hongyan, Luan, Tian
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 04.09.2024
Subjects
Animals
Anti-Inflammatory Agents - chemistry
Anti-Inflammatory Agents - pharmacology
Antineoplastic Agents, Phytogenic - chemistry
Antineoplastic Agents, Phytogenic - pharmacology
Antioxidants
Cell cycle
Chinese medicine
Cucurbitaceae - chemistry
cucurbitacin B
Cytokines
Diabetes
Disease
dosage form improvement
Drug dosages
FDA approval
Hepatitis
Humans
Inflammation
Lipids
Liver cancer
Molecular Structure
Natural products
Oxidative stress
Pesticides
Pharmaceutical industry
pharmacological action
structural modification
Structure-Activity Relationship
Toxicity
Triterpenes - chemistry
Triterpenes - pharmacology
China
dosage form improvement
pharmacological action
structural modification
cucurbitacin B
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Summary:The emergence of natural products has provided extremely valuable references for the treatment of various diseases. Cucurbitacin B, a tetracyclic triterpenoid compound isolated from cucurbitaceae and other plants, is the most abundant member of the cucurbitin family and exhibits a wide range of biological activities, including anti-inflammatory, anti-cancer, and even agricultural applications. Due to its high toxicity and narrow therapeutic window, structural modification and dosage form development are necessary to address these issues with cucurbitacin B. This paper reviews recent research progress in the pharmacological action, structural modification, and application of cucurbitacin B. This review aims to enhance understanding of advancements in this field and provide constructive suggestions for further research on cucurbitacin B.
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ISSN:1420-3049
1420-3049
DOI:10.3390/molecules29174193