Susceptibility to critical illness: reserve, response and therapy

Risk of critical illness is determined both by genetic and environmental influences, particularly those relating to infectious and cardiovascular diseases. Physiologically-based scoring systems cannot measure prior risk because they do not quantify physiological reserve independently of the acute il...

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Published inIntensive care medicine Vol. 26 Suppl 1; no. S1; pp. S57 - S063
Main Author Bion, J F
Format Journal Article
LanguageEnglish
Published United States Springer Nature B.V 01.02.2000
Subjects
Cardiovascular diseases
Clinical outcomes
Critical Care
Critical Illness
Disease
Disease Susceptibility
Education
Emergency medical care
Hospitals
Humans
Illnesses
infection
Intensive care
intervention
Mortality
Oxygen
Patients
Physiology
Risk assessment
Risk Factors
Severity of Illness Index
Variables
United Kingdom > UK
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Summary:Risk of critical illness is determined both by genetic and environmental influences, particularly those relating to infectious and cardiovascular diseases. Physiologically-based scoring systems cannot measure prior risk because they do not quantify physiological reserve independently of the acute illness. Genetic profiling could be useful for risk assessment. Early detection of critical illness involves identifying physiological 'triggers' for referral; this requires the education of nursing and medical staff in their significance. Analysis of the relationship between risk factors and interventions may need complex modelling techniques. Therapeutic strategies depend on the nature of the underlying problem: the most useful are likely to be those which enhance tissue oxygen delivery and resistance to infection.
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ISSN:0342-4642
1432-1238
DOI:10.1007/s001340051120