Nitric oxide-generating l-cysteine-grafted graphene film as a blood-contacting biomaterial

By using polyethylenimine molecules as the linker, l-cysteine was immobilized onto graphene nanosheets, endowing the biocompatible l-cysteine-functionalized graphene film with the ability for catalytic decomposition of exogenous or endogenous donors to generate nitric oxide, and thus inhibiting the...

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Published inBiomaterials science Vol. 4; no. 6; pp. 938 - 942
Main Authors Du, Zhen, Dou, Ruixia, Zu, Mian, Liu, Xueying, Yin, Wenyan, Zhao, Yuliang, Chen, Jingbo, Yan, Liang, Gu, Zhanjun
Format Journal Article
LanguageEnglish
Published England 24.06.2016
Subjects
Adhesion
Agglomeration
Biocompatible Materials - chemistry
Biocompatible Materials - metabolism
Biomaterials
Biomedical materials
Cell Proliferation
Cysteine - chemistry
Cysteine - metabolism
Endothelial Cells - metabolism
Graphene
Graphite - chemistry
Graphite - metabolism
Humans
Nitric Oxide - blood
Nitric Oxide - chemistry
Nitric Oxide - metabolism
Platelet Adhesiveness
Platelet Aggregation
Platelets
Polyethyleneimine - chemistry
Polyethylenimine
Surgical implants
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Summary:By using polyethylenimine molecules as the linker, l-cysteine was immobilized onto graphene nanosheets, endowing the biocompatible l-cysteine-functionalized graphene film with the ability for catalytic decomposition of exogenous or endogenous donors to generate nitric oxide, and thus inhibiting the platelet activation and aggregation and reducing platelet adhesion.
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ISSN:2047-4830
2047-4849
DOI:10.1039/c6bm00074f