Livedoid cutaneous metastasis of signet‐ring cell gastric carcinoma

• Published in: Journal of cutaneous pathology Vol. 48; no. 6; pp. 785 - 788
• Main Authors: Demircioğlu, Deniz, Öztürk Durmaz, Emel, Demirkesen, Cüyan, Şahin, Sedef
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.06.2021; Wiley Subscription Services, Inc
• Subjects: Biopsy; Carcinoma; Case reports; cutaneous metastasis; Gastric cancer; Inflammation; inflammatory; livedo reticularis; livedoid; Malignancy; Metastases; Metastasis; signet‐ring cell; Ulcers; cutaneous metastasis; gastric cancer; signet-ring cell; livedoid; livedo reticularis; inflammatory
• ISSN: 0303-6987; 1600-0560
• DOI: 10.1111/cup.13969

Cutaneous metastasis of gastric cancer is extremely rare. Nodular forms are more common and inflammatory forms are exceptionally encountered. Herein, we report a case of inflammatory cutaneous metastasis of signet‐ring cell gastric cancer (poorly cohesive gastric carcinoma with signet‐ring cell component) masquerading as livedo reticularis. To our knowledge, such a clinical presentation of cutaneous metastasis has not been reported for gastric cancer. It is imperative to preserve a high index of clinical suspicion for diagnosing cutaneous metastases. Our case highlights the importance of obtaining a skin biopsy in patients with a known history of internal malignancy. Bizarre, newly erupting, evolving, persistent, or treatment‐refractory dermatologic lesions (such as nodules, ulcers, erythematous, reticular, or livedoid patches) might be clues for an underlying internal malignancy and require prompt histopathological sampling. Personal medical history, histopathological examination, and immunohistochemical profiling are equally important in distinguishing primary cutaneous carcinomas from secondary metastatic deposits. Early recognition of a cutaneous metastasis might enable appropriate staging and timely intervention, thereby prolonging survival.