Serum thyrotropin responses to thyrotropin-releasing hormone in Korsakoff's syndrome

Eleven patients with DSM-III-R Korsakoff's syndrome were studied as were 11 patients with alcohol dependence syndrome (without Korsakoff's syndrome and abstinent for at least 3 years) and 11 healthy controls. All subjects underwent a thyroid-releasing hormone and thyroid-stimulating hormon...

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Bibliographic Details
Published inActa psychiatrica Scandinavica Vol. 88; no. 3; p. 218
Main Authors Thakore, J H, Dinan, T G
Format Journal Article
LanguageEnglish
Published United States 01.09.1993
Subjects
Alcohol Amnestic Disorder - blood
Alcohol Amnestic Disorder - diagnosis
Alcohol Amnestic Disorder - rehabilitation
Alcoholism - blood
Alcoholism - diagnosis
Alcoholism - rehabilitation
Female
Follow-Up Studies
Humans
Male
Middle Aged
Temperance
Thyroid Hormones - blood
Thyrotropin - blood
Thyrotropin-Releasing Hormone
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Summary:Eleven patients with DSM-III-R Korsakoff's syndrome were studied as were 11 patients with alcohol dependence syndrome (without Korsakoff's syndrome and abstinent for at least 3 years) and 11 healthy controls. All subjects underwent a thyroid-releasing hormone and thyroid-stimulating hormone stimulation test. Forty-five percent of the Korsakoff's syndrome patients had a blunted response and 18% of the chronic abstinent alcoholic group were similarly blunted. None of the controls had an attenuated response. The possible reasons for the high level of blunting are discussed.
ISSN:0001-690X
DOI:10.1111/j.1600-0447.1993.tb03442.x