A fatal case of malignant atrophic papulosis in a pediatric patient

A 17‐year‐old Caucasian boy presented with progressive left‐sided weakness, transient slurred speech, and skin lesions characterized by 3‐5 mm, pink, asymptomatic papules with white atrophic centers on his central abdomen, back, and lower extremities. Skin biopsy confirmed the diagnosis of malignant...

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Published inPediatric dermatology Vol. 39; no. 1; pp. 112 - 114
Main Authors Schaefer, Lauren S., Wampler Muskardin, Theresa, Tillema, Jan‐Mendelt, Wieland, Carilyn, Tollefson, Megha M.
Format Journal Article
LanguageEnglish
Published United States Wiley Subscription Services, Inc 01.01.2022
Subjects
Acetylsalicylic acid
Adolescent
Anticoagulants
Arteries
Biopsy
Case reports
Child
Cyclophosphamide
degos disease
Diagnosis
Early Diagnosis
eculizumab
Heparin
Humans
Immunosuppression
Male
malignant atrophic papulosis
Malignant Atrophic Papulosis - diagnosis
Malignant Atrophic Papulosis - drug therapy
Medical diagnosis
Monoclonal antibodies
Occlusion
Pediatrics
Skin
Skin Diseases
Skin lesions
treprostinil
Vascular diseases
Vein & artery diseases
degos disease
eculizumab
malignant atrophic papulosis
treprostinil
MAP
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Summary:A 17‐year‐old Caucasian boy presented with progressive left‐sided weakness, transient slurred speech, and skin lesions characterized by 3‐5 mm, pink, asymptomatic papules with white atrophic centers on his central abdomen, back, and lower extremities. Skin biopsy confirmed the diagnosis of malignant atrophic papulosis, a rare vasculopathy that leads to the occlusion of small‐ and medium‐sized arteries. He was treated with cyclophosphamide, eculizumab, treprostinil, pentoxifylline, heparin, and acetylsalicylic acid. Despite the aggressive immunosuppression, humanized monoclonal antibodies, and antiplatelet therapy, he died two months after presentation. We report this case to highlight diagnostic features, as well as to highlight the importance of early diagnosis and treatment.
ISSN:0736-8046
1525-1470
DOI:10.1111/pde.14878