Congenital neurocristic cutaneous hamartoma with poliosis: A case report

Neurocristic cutaneous hamartomas (NCH) are rare, pigmented skin lesions derived from the abnormal migration of neural crest cells. We report the case of a 57‐year‐old female with a congenital localized area of poliosis and underlying pigmented patch on her scalp. Analysis of 2 punch biopsies yielde...

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Bibliographic Details
Published inJournal of cutaneous pathology Vol. 44; no. 11; pp. 974 - 977
Main Authors Wilson, Lauren M., Beasley, Knox J., Sorrells, Timothy C., Johnson, Viviana V.
Format Journal Article
LanguageEnglish
Published Oxford, UK Blackwell Publishing Ltd 01.11.2017
Wiley Subscription Services, Inc
Subjects
Case reports
CD34 antigen
congenital
cutaneous
Dermis
Female
hamartoma
Hamartoma - congenital
Hamartoma - pathology
Humans
Literature reviews
Melanocytes
Melanoma
Middle Aged
Neoplasia
Neural crest
neurocristic
poliosis
Scalp
Skin diseases
Skin Diseases - congenital
Skin Diseases - pathology
Stroma
cutaneous
neurocristic
congenital
poliosis
hamartoma
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Summary:Neurocristic cutaneous hamartomas (NCH) are rare, pigmented skin lesions derived from the abnormal migration of neural crest cells. We report the case of a 57‐year‐old female with a congenital localized area of poliosis and underlying pigmented patch on her scalp. Analysis of 2 punch biopsies yielded features consistent with NCH. Histopathology revealed schwannian‐differentiated spindle cells and melanocytic components in the dermis. The spindle cells stained positively for S‐100 and the stroma showed a prominent CD34 staining. The melanocytes were positive for melanoma triple stain (HMB‐45, Melan A, Tyrosinase) and S‐100. As the presentation of NCH and focal poliosis has yet to be described, we will present a literature review of NCH and discuss common features and associations of poliosis.
ISSN:0303-6987
1600-0560
DOI:10.1111/cup.13027