MicroRNA155 Expression in Relation to BDCAF Scored Behçet's Disease in an Egyptian Patients' Sample

To discover the possibility of using microRNA155 (miRNA155) expression level as a biomarker of Behçet's Disease (BD) activity or remission. Thirty BD patients' white blood cells (WBCs) miRNA155 expression was measured and compared to WBCs miRNA155 expression in 15 healthy subjects. Assessm...

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Published inThe open rheumatology journal Vol. 12; no. 1; pp. 115 - 122
Main Authors Hassouna, Sally S, Tayel, Manal Y, ElKaffash, Dalal M, Abdelhady, Ahmed M, Elsayed, Eman H
Format Journal Article
LanguageEnglish
Published United Arab Emirates Bentham Open 2018
Subjects
Rheumatology
MicroRNA155
Behçet's disease
CD40
Egyptian patients
miRNA155
BDCAF
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Summary:To discover the possibility of using microRNA155 (miRNA155) expression level as a biomarker of Behçet's Disease (BD) activity or remission. Thirty BD patients' white blood cells (WBCs) miRNA155 expression was measured and compared to WBCs miRNA155 expression in 15 healthy subjects. Assessment of disease activity was done using Behçet's Disease Current Activity Form (BDCAF). miRNA155 expression significantly decreases with the increase of BD activity scored by BDCAF. Increased miRNA155 may be used as a biomarker of BD remission and thus in the disease follow up. There could be a prospect of treating the disease microRNA 155 effect enhancement.
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ISSN:1874-3129
1874-3129
DOI:10.2174/1874312901812010115