Effects of Coffee on Sirtuin-1, Homocysteine, and Cholesterol of Healthy Adults: Does the Coffee Powder Matter?

• Published in: Journal of clinical medicine Vol. 11; no. 11; p. 2985
• Main Authors: Gonçalinho, Gustavo Henrique Ferreira, Nascimento, José Rafael de Oliveira, Mioto, Bruno Mahler, Amato, Reynaldo Vicente, Moretti, Miguel Antonio, Strunz, Célia Maria Cassaro, César, Luiz Antonio Machado, Mansur, Antonio de Padua
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 25.05.2022; MDPI
• Subjects: bioactive compounds; Caffeine; cardiometabolic health; Cardiovascular disease; Cholesterol; Clinical medicine; coffee; Coffee industry; Diabetes; DNA repair; Gene expression; Glucose; High density lipoprotein; Homeostasis; Homocysteine; Hormone replacement therapy; Hypertension; Insulin resistance; Intervention; Life expectancy; Lipids; Metabolism; Metabolites; sirtuin-1; Triglycerides; Brazil; United States > US; homocysteine; Robusta; sirtuin-1; Arabica; coffee; bioactive compounds; cholesterol; cardiometabolic health
• ISSN: 2077-0383; 2077-0383
• DOI: 10.3390/jcm11112985

Background: Coffee is one of the most popular beverages globally and contains several bioactive compounds that are relevant to human health. Many nutritional strategies modulate sirtuin-1, thereby impacting aging and cardiometabolic health. This study investigated the influence of different blended coffees on serum sirtuin-1, blood lipids, and plasma homocysteine. Methods: An eight-week randomized clinical trial that included 53 healthy adults of both sexes analyzed the effects of daily intake of 450 to 600 mL of pure Arabica or blended (Arabica + Robusta) coffee intake of filtered coffee on blood sirtuin-1, lipids, and homocysteine. Results: Both Arabica and blended coffees similarly increased serum sirtuin-1 concentration, from 0.51 to 0.58 ng/mL (p = 0.004) and from 0.40 to 0.49 ng/mL (p = 0.003), respectively, without changing plasma homocysteine, folic acid, glucose, and CRP. However, the blended coffee intake increased total cholesterol from 4.70 to 5.17 mmol/L (p < 0.001) and LDL-cholesterol from 2.98 to 3.32 mmol/L (p < 0.001), as well as HDL-c from 1.26 to 1.36 mmol/L (p < 0.001). Conclusion: Both coffee powders increased sirtuin-1 expression, but our results suggest that blended coffee had hypercholesterolemic effects which could increase cardiovascular risk. Therefore, preference should be given to Arabica coffee for the best cardiometabolic benefits of coffee.