Exploration of Adhesion Molecule Expression in Cardiac Muscle of Early Atherosclerosis Dyslipidemic Sprague Dawley Rats

This study is aimed to examine the expression of ICAM-1 and VCAM-1 in cardiac tissue of dyslipidemic Sprague Dawley rats. Eight Sprague Dawley strain rats, with 150-200 gram body weight, were divided into two groups. The control group was fed a standard diet, the positive control group was fed a hig...

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Published inThe open medicinal chemistry journal Vol. 12; no. 1; pp. 124 - 129
Main Authors Wihastuti, Titin A, Aini, Fitria N, Lutfiana, Nurul C, Heriansyah, Teuku, Zamrudah, Nafisatuz
Format Journal Article
LanguageEnglish
Published United Arab Emirates Bentham Open 2018
Subjects
Medicinal Chemistry
VCAM-1
Atherosclerosis
Dyslipidemia
ICAM-1
Immunofluorescence
Adhesion
Molecule expression
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Summary:This study is aimed to examine the expression of ICAM-1 and VCAM-1 in cardiac tissue of dyslipidemic Sprague Dawley rats. Eight Sprague Dawley strain rats, with 150-200 gram body weight, were divided into two groups. The control group was fed a standard diet, the positive control group was fed a high-fat diet as our previous study for 8 weeks. The pattern of distribution of ICAM-1 and VCAM-1 in cardiac muscle cell was examined by immunofluorescence and observed with a confocal laser scanning microscope. Lipid profile was also examined at the end of the study. Independent t-test showed no differences in ICAM-1 and VCAM-1 expression in cardiac muscle of hypercholesterol-diet-fed Sprague Dawley rat compared to control. The expression of ICAM-1 and VCAM-1 in cardiac muscle did not change after the onset of atherosclerosis.
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ISSN:1874-1045
1874-1045
DOI:10.2174/1874104501812010124