FCRL3 expression is upregulated and closely correlates with TIGIT expression in regulatory T cells of patients with systemic lupus erythematosus

Using data from single‐cell RNA sequencing and flow cytometry, we initially examined the expression of FCRL3, finding it to be elevated and positively associated with TIGIT expression in the regulatory T cells of patients with systemic lupus erythematosus. This also suggests that the co‐expression o...

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Published inEuropean journal of immunology Vol. 54; no. 5; pp. e2350739 - n/a
Main Authors Bahabayi, Ayibaota, Zhang, Ya‐Hui, Yuan, Zihang, Wang, Yiying, Zhang, Zhonghui, Zeng, Xingyue, Guan, Zhao, Wang, Pingzhang, Liu, Chen
Format Journal Article
LanguageEnglish
Published Germany Wiley Subscription Services, Inc 01.05.2024
Subjects
Adult
FCRL3
Female
Flow cytometry
Humans
Immunoregulation
Lupus
Lupus Erythematosus, Systemic - genetics
Lupus Erythematosus, Systemic - immunology
Lymphocytes T
Male
Receptors, Immunologic - genetics
Receptors, Immunologic - metabolism
Systemic lupus erythematosus
T-Lymphocytes, Regulatory - immunology
TIGIT
Treg
Up-Regulation - immunology
systemic lupus erythematosus
TIGIT
FCRL3
Treg
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Summary:Using data from single‐cell RNA sequencing and flow cytometry, we initially examined the expression of FCRL3, finding it to be elevated and positively associated with TIGIT expression in the regulatory T cells of patients with systemic lupus erythematosus. This also suggests that the co‐expression of FCRL3 and TIGIT warrants further attention.
Bibliography:Ayibaota Bahabayi, Ya‐Hui Zhang, Zihang Yuan, and Yiying Wang contributed equally to the study.
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ObjectType-Correspondence-2
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ISSN:0014-2980
1521-4141
1521-4141
DOI:10.1002/eji.202350739