Acute antihypertensive effect of nifedipine on high and low salt diet

To examine the influence of sodium balance in the acute response to nifedipine, we studied 10 untreated essential hypertensive patients aged 29 to 43 years. Blood pressure was recorded with the patients fasting and lying in the supine position, and 10 mg nifedipine was administered sublingually. Blo...

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Bibliographic Details
Published inJournal of cardiovascular pharmacology Vol. 10 Suppl 10; p. S147
Main Authors Luque-Otero, M, Fernandez-Pinilla, C, Catalan, P, Martell-Claros, N, Fernandez-Cruz, A, Martinez-Gomez, M E
Format Journal Article
LanguageEnglish
Published United States 1987
Subjects
Adult
Blood Pressure
Humans
Hypertension - drug therapy
Hypertension - physiopathology
Nifedipine - therapeutic use
Sodium - urine
Sodium, Dietary - pharmacology
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Summary:To examine the influence of sodium balance in the acute response to nifedipine, we studied 10 untreated essential hypertensive patients aged 29 to 43 years. Blood pressure was recorded with the patients fasting and lying in the supine position, and 10 mg nifedipine was administered sublingually. Blood pressure was recorded again 3 h after nifedipine. Patients were studied after 1 week on both their unrestricted usual diet (NaU 206 +/- 29 mmol/day) and a low salt diet (NaU 66 +/- 8 mmol/day). The maximum hypotensive effect of nifedipine was observed at 90 min. The decrease of blood pressure tended to be greater and longer on high salt than low salt diet. Our results suggest that the acute antihypertensive effect of nifedipine is enhanced by sodium administration.
ISSN:0160-2446
DOI:10.1097/00005344-198706110-00052