Lymphomatoid papulosis type E with a CD56+ immunophenotype presenting with purpura‐like lesions

• Published in: Journal of cutaneous pathology Vol. 46; no. 7; pp. 542 - 545
• Main Authors: Ba, Wei, Yin, Guang, Yang, Jingrun, Zhang, Ziyan, Wang, Wenjuan, Zhao, Zigang, Chen, Hongxiao, Li, Chengxin
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.07.2019; Wiley Subscription Services, Inc
• Subjects: Adult; Ankle; Biopsy; CD30 antigen; CD56 antigen; CD56 Antigen - immunology; CD56 Antigen - metabolism; CD8 antigen; Female; Humans; Immunophenotyping; Lymphocytes; Lymphomatoid papulosis; Lymphomatoid Papulosis - immunology; Lymphomatoid Papulosis - metabolism; Lymphomatoid Papulosis - pathology; Neoplasm Proteins - immunology; Neoplasm Proteins - metabolism; Purpura; Purpura - immunology; Purpura - metabolism; Purpura - pathology; Skin Neoplasms - immunology; Skin Neoplasms - metabolism; Skin Neoplasms - pathology
• ISSN: 0303-6987; 1600-0560
• DOI: 10.1111/cup.13472

Lymphomatoid papulosis (LyP) type E is a recently described variant characterized by the occurrence of large necrotic eschar‐like lesions displaying microscopically angioinvasive and angiodestructive infiltrates of CD30+ lymphocytes, frequently coexpressing CD8. Rare cases of LyP type E with a CD56+ immunophenotype have been described. Herein, we describe a 36‐year‐old woman with LyP type E, characterized by purpura‐like lesions on her left ankle. Initially, she presented with left ankle swelling, petechiae and ecchymosis, and rapidly developing necrotic papules, all of which resolved spontaneously over a period of a few months without intentional therapy. Biopsy revealed CD30 and CD56 positive atypical cell infiltrates with marked angiocentricity and angiodestruction. Awareness of this rare LyP variant and its correct recognition, even if the clinical presentation is unusual, is important to avoid aggressive treatment.