Gut-liver immune and redox response in hybrid fish (Carassius cuvieri ♀ × Carassius auratus red var. ♂) after gut infection with Aeromonas hydrophila

• Published in: Comparative biochemistry and physiology. Toxicology & pharmacology Vol. 266; p. 109553
• Main Authors: Xiong, Ning-Xia, Luo, Wei-Sheng, Kuang, Xu-Ying, Wang, Fei, Fang, Zi-Xuan, Ou, Jie, Huang, Ming-Zhu, Fan, Lan-Fen, Luo, Sheng-Wei, Liu, Shao-Jun
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.04.2023
• Subjects: Aeromonas hydrophila; Aeromonas hydrophila - physiology; Animals; Antioxidant status; antioxidants; Antioxidants - metabolism; bacterial infections; Carassius auratus; Carassius cuvieri; Carps - metabolism; chemokines; Crucian carp; fish; Fish Diseases - microbiology; Fish Proteins - metabolism; Gene expressions; genes; Goldfish - metabolism; hybrids; hyperplasia; Immunity, Innate; liver; Liver - metabolism; midgut; Oxidation-Reduction; physiology; tight junctions; Crucian carp; Aeromonas hydrophila; Antioxidant status; Gene expressions
• ISSN: 1532-0456; 1878-1659
• DOI: 10.1016/j.cbpc.2023.109553

Aeromonas hydrophila can pose a great threat to fish survival. In this study, we investigated the differential immune and redox response in gut-liver axis of hybrid fish (WR) undergoing gut infection. WR anally intubated with A. hydrophila showed severe midgut injury with decreased length-to-width ratios of villi along with GC hyperplasia and enhanced antioxidant activities, but expression profiles of cytokines, chemokines, antibacterial molecules, redox sensors and tight junction proteins decreased dramatically. In contrast, immune-related gene expressions and antioxidant activities increased significantly in liver of WR following gut infection with A. hydrophila. These results highlighted the differential immune regulation and redox balance in gut-liver axis response to bacterial infection. [Display omitted] •Severe midgut injury with GC hyperplasia was observed in WR anally intubated with A. hydrophila.•Suppressions of tight junction molecules were observed in midgut of WR following gut infection.•WR receiving gut infection with A. hydrophila exhibited differential immune and redox response in gut-liver axis.