Increased levels of intercellular adhesion molecule-1 (ICAM-1) and tumor necrosis factor receptor in the cerebrospinal fluid of patients with multiple sclerosis

• Published in: Neurology Vol. 43; no. 12; p. 2679
• Main Authors: Tsukada, N, Matsuda, M, Miyagi, K, Yanagisawa, N
• Format: Journal Article
• Language: English
• Published: United States 01.12.1993
• Subjects: Adolescent; Adult; Cell Adhesion Molecules - cerebrospinal fluid; Enzyme-Linked Immunosorbent Assay; Female; Humans; Male; Middle Aged; Multiple Sclerosis - cerebrospinal fluid; Multiple Sclerosis - physiopathology; Osmolar Concentration; Receptors, Tumor Necrosis Factor - metabolism; Recurrence; Solubility
• ISSN: 0028-3878
• DOI: 10.1212/WNL.43.12.2679

We investigated the presence of soluble intercellular adhesion molecule-1 (sICAM-1) and soluble tumor necrosis factor receptor (sTNF-R) antigens in the CSF of patients with multiple sclerosis (MS) using a double-determinant ELISA. Patients with acute relapsing MS during an exacerbation (p < 0.001) and those with chronic progressive MS (p < 0.001) had significantly increased CSF levels of sICAM-1 compared with subjects with other neurologic diseases. CSF levels of sTNF-R were also significantly increased in patients with acute relapsing MS during an exacerbation (p < 0.001) and chronic progressive MS (p < 0.001) compared with subjects with other neurologic diseases. CSF levels of sICAM-1 and sTNF-R were positively correlated in patients with acute relapsing MS during an exacerbation (r = 0.81, p < 0.01) and chronic progressive MS (r = 0.86, p < 0.001). These results suggest that active immune reactions involving ICAM-1 and TNF-R production are present within the CNS and that both sICAM-1 and sTNF-R are important immunologic markers of the clinical activity of MS.