Identification of four patients with colistin-resistant Escherichia coli containing the mobile colistin resistance mcr -1 gene from a single health system in Michigan

• Published in: Infection control and hospital epidemiology Vol. 40; no. 9; pp. 1059 - 1062
• Main Authors: Henig, Oryan, Rojas, Laura J., Bachman, Michael A., Rudin, Susan D., Brennan, Brenda M., Soehnlen, Marty K., Jones, Kelly L., Mills, John P., Dombecki, Carey R., Valyko, Amanda M., Marshall, Steven H., Bonomo, Robert A., Kaye, Keith S., Washer, Laraine
• Format: Journal Article
• Language: English
• Published: United States Cambridge University Press 01.09.2019
• Subjects: Aged; Antibiotics; Bladder cancer; Colistin - pharmacology; Diabetes; Drug Resistance, Bacterial - genetics; E coli; Escherichia coli - genetics; Escherichia coli Infections - genetics; Escherichia coli Infections - microbiology; Escherichia coli Proteins - genetics; Female; Genes; Gynecology; Hospitalization; Humans; Intrauterine devices; IUD; Laboratories; Male; Michigan; Microbial Sensitivity Tests; Phylogenetics; Plasmids; Salmonella; Spina bifida; Surveillance; Transplants & implants; Travel; Urinary tract infections; Urine; Virulence; Whole Genome Sequencing; Young Adult; Michigan; Lebanon; Mexico; United States > US; China
• ISSN: 0899-823X; 1559-6834; 1559-6834
• DOI: 10.1017/ice.2019.177

Clinical Enterobacteriacae isolates with a colistin minimum inhibitory concentration (MIC) ≥4 mg/L from a United States hospital were screened for the mcr-1 gene using real-time polymerase chain reaction (RT-PCR) and confirmed by whole-genome sequencing. Four colistin-resistant Escherichia coli i solates contained mcr-1 . Two isolates belonged to the same sequence type (ST-632). All subjects had prior international travel and antimicrobial exposure.