Multi-step cefazolin sodium release from bioactive TiO2 nanotubes: Surface and polymer coverage effects

Bacterial implant-related infections have been pointed out as the leading cause of metal implant failure. Recently, nanotexturization of biomaterials surface associated with antibiotic loading revealed itself as a promising strategy for enhancing osseointegration while mitigating bacterial infection...

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Published inJournal of materials research Vol. 36; no. 7; pp. 1510 - 1523
Main Authors Simon, Anna Paulla, Ferreira, Carlise Hannel, Santos, Vidiany Aparecida Queiroz, Rodrigues, Andressa, Santos, Janaina Soares, Trivinho-Strixino, Francisco, Marques, Patricia Teixeira, Zorel, Henrique Emilio, Sikora, Mariana de Souza
Format Journal Article
LanguageEnglish
Published Cham Springer International Publishing 14.04.2021
Springer Nature B.V
Subjects
Antibiotics
Applied and Technical Physics
Bacteria
Biomaterials
Biomedical materials
Chemistry and Materials Science
Chitosan
Inorganic Chemistry
Materials Engineering
Materials research
Materials Science
Nanotechnology
Polymers
Sodium
Surgical implants
Titanium
Titanium dioxide
Polymer
Biomaterial
Nanostructure
Coating
Kinetics
Electrochemical synthesis
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Summary:Bacterial implant-related infections have been pointed out as the leading cause of metal implant failure. Recently, nanotexturization of biomaterials surface associated with antibiotic loading revealed itself as a promising strategy for enhancing osseointegration while mitigating bacterial infections. However, fewer studies describe the effects of multi-step local drug delivery. This study investigates 1 mg Cefazolin Sodium (CS) release from anodic nanotextured titanium-based devices and the effect of polymer coverage with differential aqua solubility characteristics (Chitosan—CH and Carboxymethylcellulose—CM). Results show that larger inner pore diameters are related to longer drug release times on uncovered samples. The polymeric coverage decreases the release rates, highlighting the Carboxymethylcellulose boosting the Cefazolin release time by 51–77 fold. All biomaterials exhibited a low or absent hemolytic activity and considerable bacteria inactivation. In summary, 40 °C/CM-based samples present the most promising results for drug release devices. Graphic abstract
ISSN:0884-2914
2044-5326
DOI:10.1557/s43578-021-00202-9