Synthesis and Anti-Vibrio Activity of Gallic Acid Derivatives Containing Acyl Thiourea Phenol

• Published in: Chemistry of natural compounds Vol. 60; no. 1; pp. 105 - 109
• Main Authors: Wu, Yu-yu, Qiu, Min, Liang, Xin-wen, Gao, Tian-tian, Chen, Chao, Su, Zi-qin, Liu, Wei-wei
• Format: Journal Article
• Language: English
• Published: New York Springer US 2024; Springer Nature; Springer Nature B.V
• Subjects: Bacteria; Chemistry; Chemistry and Materials Science; Chemistry, Medicinal; Chemistry, Organic; Chemistry/Food Science; Gallic acid; Life Sciences & Biomedicine; Organic Chemistry; Pharmacology & Pharmacy; Physical Sciences; Plant Sciences; Raw materials; Science & Technology; Synthesis; Thiourea derivatives; Thioureas; antibacterial activity; marine; gallic acid derivatives; DESIGN; marine Vibrio; CANCER; ESTERS
• ISSN: 0009-3130; 1573-8388
• DOI: 10.1007/s10600-024-04269-8

A series of gallic acid derivatives containing acyl thiourea phenol were designed and synthesized with gallic acid as a raw material, and their antibacterial activities were evaluated: the synthesized acyl thiourea phenol derivatives of gallic acid had certain anti- Vibrio activity at 1 mg/mL; compounds 4a and 4c showed good inhibitory activity against Vibrio harveyi , MIC was 0.0156 mg/mL; compound 4f also showed certain anti- Vibrio cholerae activity, MIC was 0.0313 mg/mL; compound 4g showed anti- Vibrio parahaemolyticus activity, MIC was 0.0156 mg/mL; this series of compounds has poor inhibitory activity against Vibrio vulnificus. Only compounds 4a , 4c , 4e , 4g , and 4j have weak inhibitory activity against Vibrio vulnificus , with MIC of 0.125 mg/mL.