Quinidine-induced agranulocytosis of abrupt onset

Drug-induced agranulocytosis is a clinical entity characterized by a selective reduction of circulating neutrophils, usually to a level less than 0.2 x 10(9)/l in relation to the administration of the drug. Quinidine is an antiarrhythmic agent widely used on an outpatient basis with some well-known...

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Bibliographic Details
Published inActa haematologica Vol. 84; no. 1; p. 43
Main Authors Sureda, A, Hernández Madrid, A, Pérez Vaquero, M A, Pérez de Oteyza, J, Escribano, L, Odriozola, J
Format Journal Article
LanguageEnglish
Published Switzerland 1990
Subjects
Acute Disease
Agranulocytosis - blood
Agranulocytosis - chemically induced
Atrial Fibrillation - blood
Atrial Fibrillation - complications
Atrial Fibrillation - drug therapy
Humans
Leukocyte Count - drug effects
Male
Middle Aged
Quinidine - adverse effects
Time Factors
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Summary:Drug-induced agranulocytosis is a clinical entity characterized by a selective reduction of circulating neutrophils, usually to a level less than 0.2 x 10(9)/l in relation to the administration of the drug. Quinidine is an antiarrhythmic agent widely used on an outpatient basis with some well-known hematological side effects. Its midterm administration has been related to a few cases of agranulocytosis. Herein, we describe the case of a 60-year-old man with atrial fibrillation who presented quinidine-induced agranulocytosis of abrupt onset only 3 days after the exposure to the drug, recovering normal levels of neutrophils during the 3rd hospitalization day. Pathogenic mechanisms are discussed.
ISSN:0001-5792
DOI:10.1159/000205026