A novel mucoadhesive polymer film composed of carbopol, poloxamer and hydroxypropylmethylcellulose

Using the casting method novel mucoadhesive polymer blend film consisting of Carbopol, poloxamer, and hydroxypropylmethylcellulose (HPMC) was prepared and characterized. Triamcinolone acetonide (TAA) was loaded into Carbopol/poloxamer/HPMC polymer blend film. Carbonyl band of Carbopol in Carbopol/po...

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Bibliographic Details
Published inArchives of pharmacal research Vol. 30; no. 3; pp. 381 - 386
Main Authors Kim, Tae Hee, Ahn, Jae Soon, Choi, Hoo Kyun, Choi, Yun Jaie, Cho, Chong Su
Format Journal Article
LanguageEnglish
Published Korea (South) 대한약학회 01.03.2007
Subjects
Acrylic Resins
Adhesiveness
Drug Delivery Systems
Hypromellose Derivatives
Methylcellulose - administration & dosage
Methylcellulose - analogs & derivatives
Methylcellulose - chemistry
Mucous Membrane - metabolism
Poloxamer - administration & dosage
Poloxamer - chemistry
Polyvinyls - administration & dosage
Polyvinyls - chemistry
Spectroscopy, Fourier Transform Infrared
Triamcinolone Acetonide - administration & dosage
약학
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Summary:Using the casting method novel mucoadhesive polymer blend film consisting of Carbopol, poloxamer, and hydroxypropylmethylcellulose (HPMC) was prepared and characterized. Triamcinolone acetonide (TAA) was loaded into Carbopol/poloxamer/HPMC polymer blend film. Carbonyl band of Carbopol in Carbopol/poloxamer/HPMC shifted to longer wavenumber than that of Carbopol in Carbopol/poloxamer due to the hydrogen bonding among Carbopol, poloxamer, and HPMC. Tan delta peak assigned to glass transition temperature (Tg) of HPMC shifted to low temperature due to increased flexibility caused by increased poloxamer content in polymer blend films. Swelling ratio of Carbopol/poloxamer/HPMC films was lowest in Carbopoll poloxamer/HPMC at mixing ratio of 35/30/35 (wt/wt/wt). Adhesive force of Carbopol/poloxamer/HPMC films increased with increasing HPMC content in Carbopol/poloxamer/HPMC polymer blend film and increasing hydroxypropyl group content in HPMC due to hydrophobic property of HPMC although bioadhesive force was highest at mixing ratio of 35/30/35 (wt/wt/ wt). Release of TAA from TAA-loaded Carbopol/poloxamer/HPMC polymer blend film in vitro increased with increasing loading content of drug.
Bibliography:ObjectType-Article-1
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content type line 23
G704-000010.2007.30.3.011
ISSN:0253-6269
1976-3786
DOI:10.1007/bf02977622