Effect of liver hydrolysate on hepatic proliferation in regenerating rat liver

The effect of liver hydrolysate (LH) derived from bovine liver on rat liver regeneration after partial hepatectomy (PH) were investigated. Oral administration of LH increased rat liver weight dose-dependently at 24 h after PH. Hepatic ornithine decarboxylase (ODC) activity and proliferating cell nuc...

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Published inNihon yakurigaku zasshi Vol. 114; no. 4; p. 233
Main Authors Fukuda, Y, Sawata, M, Washizuka, M, Higashino, R, Fukuta, Y, Tanaka, Y, Takei, M
Format Journal Article
LanguageJapanese
Published Japan 1999
Subjects
Animals
Cattle
Cell Division - drug effects
Dose-Response Relationship, Drug
Hepatectomy
Liver - chemistry
Liver - cytology
Liver Regeneration - drug effects
Male
Ornithine Decarboxylase - metabolism
Proliferating Cell Nuclear Antigen - metabolism
Protein Hydrolysates - pharmacology
Rats
Rats, Wistar
Stimulation, Chemical
Time Factors
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Summary:The effect of liver hydrolysate (LH) derived from bovine liver on rat liver regeneration after partial hepatectomy (PH) were investigated. Oral administration of LH increased rat liver weight dose-dependently at 24 h after PH. Hepatic ornithine decarboxylase (ODC) activity and proliferating cell nuclear antigen (PCNA) labeling index were measured in regenerating rat liver as markers of cell proliferation. ODC activities at 4 and 24 h after PH were significantly increased by LH administration. PCNA labeling index at 24 h after PH were also increased by LH administration. These results suggest that LH stimulates liver regeneration in partially hepatectomized rats.
ISSN:0015-5691
DOI:10.1254/fpj.114.233