A mixed-ligand Zn(II)-MOF: sensitive detection of Cr(VI) ion in water and neuroprotective effect on CO poisoning patients by reducing ROS production and oxidative stress

• Published in: Journal of the Iranian Chemical Society Vol. 18; no. 11; pp. 2945 - 2951
• Main Authors: Wang, Su-E, Zhong, Xiao-ling, Huang, Fang-ling, Hao, You-Guo, Hao, Yu-Gui, Peng, Zheng-Rong
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.11.2021; Springer Nature B.V
• Subjects: Analytical Chemistry; Benzene; Biochemistry; Carbon monoxide; Carbon monoxide poisoning; Chemistry; Chemistry and Materials Science; Inorganic Chemistry; Ligands; Metal-organic frameworks; Neurons; Organic Chemistry; Original Paper; Physical Chemistry; Poisoning; Single crystals; Superoxide dismutase; Zinc; Oxidative stress; CO poisoning patients; Luminescent sensor; Zn(II)-MOF
• ISSN: 1735-207X; 1735-2428
• DOI: 10.1007/s13738-021-02243-7

In the current study, by using the mixed ligand approach, a novel 2D metal–organic framework (MOF), [Zn(Hssa)(1,4-dtb)·H 2 O] n (H 3 ssa = 5-sulfosalicylic acid, dtb = 1,4-di(4H-1,2,4-triazol-4-yl)benzene) was synthesized with a high yield under solvothermal reaction conditions and through the elemental analysis and the single-crystal X-ray diffraction. Luminescence studies demonstrate that 1 is able to be utilized as a strongly sensitive luminescent sensor for Cr 2 O 7 2− and CrO 4 2− in H 2 O. Furthermore, the neuroprotective effect of the compound on CO poisoning patients was evaluated in biological research. The real-time RT-PCR was conducted to study the expression level of the ROS-related genes in the neurons. In addition to this, the activation of the superoxide dismutase (SOD) in the neurons was measured after treatment of the compound.