The Effect of Sepsis on Myocardial Function: A Review of Pathophysiology, Diagnostic Criteria, and Treatment

Sepsis remains a worldwide challenge for physicians with many patients admitted to ICUs with septic shock. Septic shock management involves targeted treatment to control infections, reduce end-organ damage, and reverse the injury. Sepsis-induced myocardial dysfunction or septic cardiomyopathy remain...

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Published inCurēus (Palo Alto, CA) Vol. 14; no. 6; p. e26178
Main Authors Khalid, Nabeeha, Patel, Pragnesh D, Alghareeb, Rahmah, Hussain, Afshan, Maheshwari, Marvi V
Format Journal Article
LanguageEnglish
Published Palo Alto Cureus Inc 21.06.2022
Cureus
Subjects
Apoptosis
Cardiology
Cardiomyopathy
Cytokines
Ejection fraction
Free radicals
Heart failure
Hemodynamics
Hospital costs
Hypotension
Hypoxia
Infectious Disease
Internal Medicine
Medical diagnosis
Metabolism
Mortality
Nitric oxide
Observational studies
Pathophysiology
Sepsis
Tumor necrosis factor-TNF
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Summary:Sepsis remains a worldwide challenge for physicians with many patients admitted to ICUs with septic shock. Septic shock management involves targeted treatment to control infections, reduce end-organ damage, and reverse the injury. Sepsis-induced myocardial dysfunction or septic cardiomyopathy remains an avenue to be explored with regard to underlying pathophysiology and definite treatment guidelines. This article has compiled various studies to explain the possible mechanisms involved in the development of septic cardiomyopathy and the existing diagnostic criteria including radiological and laboratory tests to assess septic cardiomyopathy. Furthermore, the article highlights management options currently available for physicians dealing with myocardial dysfunction secondary to sepsis.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:2168-8184
2168-8184
DOI:10.7759/cureus.26178