Fe3O4@Au@SiO2 Core–Shell Nanoparticles: Synthesis,  Characterization, Investigations of Its Influence on Cell Lines Using  a NIR Laser and an Alternating Magnetic Field

Core–shell nanoparticles (CSNPs) have attracted attention in biomedical applications as they have highly useful materials with modified characteristics, such as high stability, dispersibility, higher permeability to certain target cells and reduction in consumption of precious materials. Synthesis o...

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Bibliographic Details
Published inJournal of inorganic and organometallic polymers and materials Vol. 32; no. 2; pp. 478 - 485
Main Authors Abdallah, Rusul Mohammed, Al-Haddad, Raad M. S.
Format Journal Article
LanguageEnglish
Published New York Springer US 01.02.2022
Springer Nature B.V
Subjects
Biocompatibility
Biomedical materials
Cell death
Chemistry
Chemistry and Materials Science
Core-shell particles
Field emission microscopy
Gold
Inorganic Chemistry
Iron oxides
Magnetic fields
Magnetic properties
Nanoparticles
Optical properties
Organic Chemistry
Polymer Sciences
Silicon dioxide
Stability analysis
Synthesis
@Au@SiO
CSNPs
Optical properties
Alternating magnetic field
NIR laser
MTT assay
Fe
O
Magnetic properties
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Summary:Core–shell nanoparticles (CSNPs) have attracted attention in biomedical applications as they have highly useful materials with modified characteristics, such as high stability, dispersibility, higher permeability to certain target cells and reduction in consumption of precious materials. Synthesis of core–multishell nanoparticles with suitable sizes, structural characteristics and absorption using simple methods continues to be a challenge. In this study, Fe 3 O 4 @ Au @ SiO 2  CSNPs were synthesized in three stages to control their size and the potential for tuning their properties. Field emission scanning electron microscope images confirmed that Fe 3 O 4 @ Au @ SiO 2 CSNPs have a small particle size of about 22.5 nm, average crystalline size in X-ray diffractometer analysis was 22.8 nm, stability was about − 49.1 mV, and synthesis with magnetic and optical properties improved their biocompatibility. Treatment of CAL-51 and HBL-100 cell lines by Fe 3 O 4 @ Au @ SiO 2  CSNPs under NIR laser and alternating magnetic field generated enough heat to increase cell death.
ISSN:1574-1443
1574-1451
DOI:10.1007/s10904-021-02136-5